منابع مشابه
Ku autoantigen: a multifunctional DNA-binding protein.
Ku is a heterodimeric protein composed of approximately 70- and approximately 80-kDa subunits (Ku70 and Ku80) originally identified as an autoantigen recognized by the sera of patients with autoimmune diseases. Ku has high binding affinity for DNA ends and that is why originally it was known as a DNA end binding protein, but now it is known to also bind the DNA structure at nicks, gaps, hairpin...
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English A deep philosophical divide exists between ‘strictly objective’ scientists, who believe that engaging in civic debates undermines objectivity, and ‘citizen scientists’, who believe scientists can – and at times should – help decision makers incorporate sound scientific knowledge. Here we suggest that the threat posed to scientific objectivity by the escalating politicisation of science ...
متن کاملA bridge over troubled waters.
Lung transplantation (LTx) remains the only therapeutic strategy for the treatment of end-stage respiratory failure in selected patients [1,2]. However, clinical scenario of LTx is rapidly changing. Two aspects still characterize LTx in comparison with the transplant of other solid organs. First, only a limited number of lung grafts is considered suitable for transplant within the donors’ pool....
متن کاملKu binds telomeric DNA in vitro.
Ku is a heterodimeric protein with high binding affinity for ends, nicks, and gaps in double-stranded DNA. Both in mammalian cells and in budding yeast, Ku plays a role in nonhomologous end joining in the double strand break repair pathway. However, Ku has a more significant role in DNA repair in mammalian cells compared with yeast, in which a homology-dependent pathway is the predominant one. ...
متن کاملDNA repair: How Ku makes ends meet
The recently determined crystal structure of the Ku heterodimer, in both DNA-bound and unbound forms, has shed new light on the mechanism by which this protein fulfills its key role in the repair of DNA double-strand breaks.
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ژورنال
عنوان ژورنال: Structure
سال: 2001
ISSN: 0969-2126
DOI: 10.1016/s0969-2126(01)00658-x